Association of infertility and methylenetetrahydrofolate reductase genotypes in Turkish couples

Purpose: Infertility is described as unexplained when all of the tests a basic infertility evaluation return within normal limits and present in 15% infertile couples. Some studies indicate that there an association between methylenetetrahydrofolate reductase (MTHFR C677T A1298C) mutations male or female grown adults. The objective this study was to analyze distributions MTHFR’s A1298C genotypes couples with fertility problems (UFP) healthy controls.
 Materials Methods: Two common variants MTHFR gene were screened (n =60 for polymorphism; n=62 polymorphism) controls from Cukurova region Turkey. detected by SNP analysis (Fragment analysis) kit multiplex PCR amplification/ligation products. Homocysteine levels (in serum) determined human hcy ELISA folate values Beckman coulter Unicel DxI 800 chemiluminescence test at Central Laboratory Balcali Hospital University.
 Results: In study, polymorphism not found. However, we found males UFP (%7) (%19). A statistically significant difference observed control groups regarding i) homocysteine heterozygous individuals; ii) iii) heterozygous, homozygous iv) v) vi) individuals.
 Conclusion: etiopathogenesis remains largely unexplored. relationship folate/homocysteine findings polymorphisms under clear. results our support problems.